Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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COVID-19 Response

Please know that you have the full support of the CTSI-CN as we navigate this unprecedented time. As COVID-19 continues to evolve, we are following the lead from Children's National Hospital and George Washington University and adjusting our onsite presence. Though physical offices are temporarily closed, the CTSI-CN remains open for business virtually. This allows us to continue our work with the researchers we currently serve and presents an opportunity to help researchers who have yet to use our services. For questions, contact our CTSI-CN Navigators. To request support, go to SPARC.

  • Jun
    11
    Thu, 06/11/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Jul
    9
    Thu, 07/09/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Aug
    13
    Thu, 08/13/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Sep
    10
    Thu, 09/10/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Oct
    8
    Thu, 10/08/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Nov
    12
    Thu, 11/12/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Dec
    10
    Thu, 12/10/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

Support Pediatric Research

Support care. Fund research. Improve lives. Children’s National Hospital takes on some of the most daunting medical research issues to improve children’s lives. Our experts develop therapies, find cures, and improve children's health in our community, across the nation, and around the world. Click here to learn more and offer your support for Pediatric Research at Children's National. Donations contribute to innovative research in a wide range of programs.