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i2b2 / ACT Network (SHRINE)

Please note: Currently the following resources are only available for study feasibility and cohort discovery. They are not yet available for recruitment purposes.  approval of an "honest broker" process to enable recruitment  is pending.


What is this resource?

i2b2, or Informatics for Integrating Biology & the Bedside, is an NIH-funded scalable informatics framework that links data warehouses across partner institutions. Locally, i2b2 facilitates exploration and query of the clinical data within PowerChart that has been de-identified and aggregated. In doing so, i2b2 helps with study feasibility and cohort discovery by allowing a researcher to query various inclusion/exclusion criteria, as well as ascertain the potential for recruitment.

SHRINE, or the Shared Health Research Information Network, is integrated into the i2b2 platform and supports multi-site research by enabling study feasibility and cohort discovery at partnered institutions.

The ACT Network is a real-time platform allowing researchers to explore and validate feasibility for clinical studies across the NCATS Clinical and Translational Science Award (CTSA) consortium, from their desktops. ACT helps researchers design and complete clinical studies, and is secure, HIPAA-compliant and IRB-approved.


At Children’s National Health System both i2b2, SHRINE, and ACT are support by CTSI-CN's INformatic System for Integrating Genomics, Health and Translational Sciences (INSIGHTS) program.

Please Note: As both tools currently only allow access to de-identified, aggregate data no IRB approval is required.

Who can use this resource?

All Children’s National Health System research faculty and staff can utilize i2b2/ACT Network.

How much does access to this resource cost?

i2b2/ACT Network is offered at no cost.  To see the cost of other CTSI-CN resources, please visit SPARC Request.

How do I access this resource?

To learn more and to register for i2b2/ACT Netowrk please visit: BearINSIGHTS System Access Request

To request direct assistance or information regarding i2b2/ACT Network, please register for a “Recruitment Strategy and Support" Consultation via SPARC Request.

Who should I contact for more information?

Please visit the CTSI-CN Faculty and Staff Directory and select the "Clinical Research Navigator" service area to find the person responsible for this resource.

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