Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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Front

Events

  • Aug
    21
    Characterization of Critically Ill Patients: A Clinical Application of the Health Facts Data Set
    Tue, 08/21/2018 - 12:00 to 13:00
     Please join the CTSI-CN Informatics Core for a discussion about using Health Facts EMR data to characterize critically ill pediatric patients . 
  • Aug
    22
    Epigenome-Wide Meta-Analysis of DNA Methylation and Childhood Asthma
    Wed, 08/22/2018 - 14:00 to 15:00
      The CTSI-CN BERD Module is pleased to host Sarah Reese, of the National Institute on Aging, who will discuss “Epigenome-Wide Meta-Analysis OF DNA Methylation and Childhood Asthma”. 
  • Aug
    30
    Protocol Builder - Advanced Webinar
    Thu, 08/30/2018 - 15:00 to 16:00
    Join BRANY (Biomedical Research Alliance of New York), the creator of Protocol Builder for a free advanced-level webinar/live demo of this novel protocol development tool. Primarily developed for Residents and New Investigators (but open to all users), this session will focus on advanced features including References Library import from external sources, advanced collaboration features, and summary of changes.
More Events

News

  • NCATS Director's Corner
    June 7th, 2018

    Translating Translation "NCATS is unique at NIH in that the name in the Center’s mission — “translation” — has a firmly
    established meaning that is generally associated with languages, not biomedical research. By contrast, other NIH
    components are named for widely known medical problems, such as cancer, diabetes and stroke." 

  • Crafting a Science News Release
    June 4th, 2018

    "The modern news release is now directly consumed by the public. Here are some of the best practices gathered by NIH
    communications offices for writing clear news releases that also inform the public about a scientific finding."

  • Be Skeptical About Biomarkers and Surrogate Endpoints
    June 4th, 2018

    In late April, Dr. Mike Lauer, NIH Deputy Director for Extramural Reserach, wrote about the benefits and drawbacks
    of using surrogate endpoints in clinical trials. Read his thoughts here...

More News

Impact

Has the CTSI-CN has supported your research? Tell us about it here.  

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