Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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Front

  • Apr
    20
    Fri, 04/20/2018 - 11:00

    The CTSI-CN is pleased to continue to offer Research Electronic Data Capture (REDCap) training to the Children's National and GW research communities. Please join us for REDCap 102, an intensive, hands-on Surveys, Longitudinal Studies and Applications course!

  • Apr
    24
    Tue, 04/24/2018 - 13:00 to 14:00

    Women at Children's Hospital (WATCH)
    "Brown Bag" Lunch and Learns  

  • May
    4
    Fri, 05/04/2018 - 15:00 to 16:00

    Join BRANY (Biomedical Research Alliance of New York), the creator of Protocol Builder for a free advanced webinar/live demo of this novel protocol development tool. Designed to help you and your colleagues get the most out of Protocol Builder, this session will focus on advanced Protocol Builder features, including References Library import from external sources, advanced collaboration features, and summary of changes. The session will run around 45 minutes and will end with an open question and answer session.

  • March 19th, 2018

    Join the National Research Mentoring Network (NRMN) for the 2018 MyMentor mystery series titled "The Puzzle of Missing Information." Taking place the last Thursday of each month from March to July, this webinar series will cover a wide range of topics and will provide hot tips for both novice and experienced researchers.

  • February 16th, 2018

    The CTSI-CN announces the 2018-2019 Request for Applications (RFA) for the Mentored Career Development Award (KL2). Please review the RFA in detail to learn more about this funding opportunity. 

  • February 2nd, 2018
    Patients Are Key to Rare Disease Day at NIH
    There are about 7,000 diseases officially defined as “rare,” or affecting fewer than 200,000 people in the U.S.; only a few hundred of these diseases have any approved treatment.

Impact

Has the CTSI-CN has supported your research? Tell us about it here.  

Support Pediatric Research

Support care. Fund research. Improve lives. Children’s National takes on some of the most daunting medical research issues to improve children’s lives. Our experts develop therapies, find cures, and improve children's health in our community, across the nation, and around the world. Click here to learn more and offer your support for Pediatric Research at Children's National. Donations contribute to innovative research in a wide range of programs.