Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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Events

  • Nov
    13
    FDA's Clinical Investigator Training Course
    Tue, 11/13/2018 (All day) to Thu, 11/15/2018 (All day)
    Experts from FDA’s Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER), Center for Devices and Radiological Health (CDRH), the University of Maryland, and the University of Pennsylvania will provide a deep dive into the scientific background and practical methodology needed when conducting clinical trials.
     
  • Nov
    14
    REDCap 101 Hands-On Training: Database Design
    Wed, 11/14/2018 - 12:30 to 14:30
    The Clinical and Translational Science Institute at Children's National (CTSI-CN) is pleased to continue to offer Research Electronic Data Capture (REDCap) training to the Children's National and GW research communities.
  • Nov
    15
    Protocol Builder - Introductory Webinar
    Thu, 11/15/2018 - 15:00 to 16:00
    Join BRANY (Biomedical Research Alliance of New York), the creator of Protocol Builder for a free introductory webinar/live demo of this novel protocol development tool. Designed to help you and your colleagues get more out of Protocol Builder faster, this session will focus on general Protocol Builder use for investigators, research administration and residency programs. 
  • Nov
    20
    REDCap 102: Surveys, Longitudinal Studies and Application
    Tue, 11/20/2018 - 13:30 to 15:30
    The Clinical and Translational Science Institute at Children's National (CTSI-CN) is pleased to continue to offer Research Electronic Data Capture (REDCap) training to the Children's National and GW research communities.
     
  • Nov
    26
    Discover SCIENCE with Dr. Bear: All about Sleep!
    Mon, 11/26/2018 - 16:00 to 17:00
    Come join the SCIENCE team for fun science activities, art projects and health learning fun for kids and thier caregivers. 
  • Nov
    29
    Protocol Builder - Advanced Webinar
    Thu, 11/29/2018 - 15:00 to 16:00
    Join BRANY (Biomedical Research Alliance of New York), the creator of Protocol Builder for a free advanced-level webinar/live demo of this novel protocol development tool. Primarily developed for Residents and New Investigators (but open to all users), this session will focus on advanced features including References Library import from external sources, advanced collaboration features, and summary of changes. 
  • Dec
    4
    Informatics Seminar: Richard Amdur, Chief of Biostatistics at the VA Medical Center in Washington, DC
    Tue, 12/04/2018 - 12:00 to 13:00
     
    Richard Amdur, PhD will be speaking at our Informatics Seminar. Dr. Amdur is a lead biostatistician at GWU, and Chief of Biostatistics at the Washington DC VA Medical Center.
  • Dec
    5
    ResearchMatch/i2b2 Training
    Wed, 12/05/2018 - 13:00 to 14:00
     
    Get the basics on ResearchMatch and i2b2, and use them for Cohort discovery and Recruitment. You have free access to these tools through the CTSI-CN. 
  • Dec
    6
    GW Post-Award Management Training Series: "Keys to a Successful Award Closeout"
    Thu, 12/06/2018 - 09:30 to 12:30

  • Dec
    7
    Statistical Modeling & Machine Learning Workshop
    Fri, 12/07/2018 - 09:00 to 16:00
    This free, one-day workshop will introduce three methods of AI data analysis in a beginner-friendly environment through a mix of theory and hands-on practice.
  • Dec
    8
    satRday DC--R and Data Science Conference at GWU
    Sat, 12/08/2018 - 09:00 to 17:00
    Interested in learning more about R and data science? Would you like a chance to get to know other "useRs" in an inclusive, supportive and respectful environment, at a community organized and focused conference
  • Dec
    13
    Protocol Builder - Introductory Webinar
    Thu, 12/13/2018 - 15:00 to 16:00
    Join BRANY (Biomedical Research Alliance of New York), the creator of Protocol Builder for a free introductory webinar/live demo of this novel protocol development tool. Designed to help you and your colleagues get more out of Protocol Builder faster, this session will focus on general Protocol Builder use for investigators, research administration and residency programs.
  • Dec
    13
    The Writing Institute - Naomi Luban, MD
    Thu, 12/13/2018 - 16:00 to 17:30
    The Writing Institute is designed to help YOU develop the habit of writing. The second Thursday of every month, a talented author from Children's National will describe how they made writing a habit. GW faculty and staff are welcome to attend. WebEx is not available. 
  • Dec
    17
    Discover SCIENCE with Dr. Bear: All about Sleep!
    Mon, 12/17/2018 - 16:00 to 17:00
    Come join the SCIENCE team for fun science activities, art projects and health learning fun for kids and thier caregivers
  • Jan
    10
    The Writing Institute - Catherine Bollard, MD
    Thu, 01/10/2019 - 16:00 to 17:30
    The Writing Institute is designed to help YOU develop the habit of writing. The second Thursday of every month, a talented author from Children's National will describe how they made writing a habit. GW faculty and staff are welcome to attend. WebEx is not available. 
More Events

News

  • 2019 Healthcare Hackathon
    November 7th, 2018
    The CTSI-CN proudly announces the 2019 Healthcare Hackathon. You don't have to be a programmer to have an idea for healthcare software. Finalists will attend a half-day hackathon to develop their ideas into prototypes. Winners receive funding to bring their app to life. Ideas are due January 4, 2019.
  • Engage with the Community: Discover SCIENCE with Dr. Bear
    October 23rd, 2018
     
    Volunteers needed for Discover SCIENCE with Dr. Bear, a series of free STEAM events at DC libraries this fall and winter. Children are invited to do science activities, art projects, and learn about health. Volunteers will engage attendees in conversation about science topics and assist with activites. 
  • CTSI-CN Voucher RFA Released
    October 17th, 2018

    The Collaboration and Multidisciplinary Team Science (CMTS) module of the CTSI-CN announces the FALL 2018 Voucher Award Program. Multiple awards (≤ $4K each) are available for “shovel-ready” projects that will lead to paper and/or proposal submissions within 6 months of the award. All high impact research relevant to health and well-being throughout the lifespan is eligible. Support is not limited to pediatric research. Applications are due November 27, 2018. 

  • NIH Extension Policy for Early Stage Investigator Status
    September 25th, 2018

    NIH considers extension requests for Early Stage Investigators (ESI) on a case-by-case basis for medical concerns, disability, extended periods of clinical training, natural disasters, and active duty military service. Effective immediately, NIH will approve an ESI extension of one year for childbirth within the ESI period. Learn more about the policy change HERE. 

  • NIH Office of Clinical Research offers a free, online intro to clinical research course
    September 25th, 2018
    The NIH Office of Clinical Research is offering a free, online, self-paced course.  The course runs from October 1, 2018 through June 20, 2019. Click the title for additional details. 
  • Writing Institute 2018-2019
    September 24th, 2018

    The Writing Institute is designed to help YOU develop the habit of writing. The second Thursday of every month, a talented author from Children's National will describe how they made writing a habit. GW faculty and staff are welcome to attend. WebEx is not available. 

  • Children's National Funding Announcement
    September 21st, 2018

    The Board of Visitors is accepting Letters of Intent from Children's National staff. Letters are due by October 1, 2018. 

  • George Washington offers a fall series of award trainings
    September 20th, 2018
    Starting next week, George Washington University's Office of Sponsored Projects is offering a fall series of award management trainings from pre- to post-award on a variety of focused topics. Click the title to learn more and register. 
  • Funding for the mobilize snorkel workshop: Rapid Biomedical Knowledge Base Construction from Text
    September 12th, 2018

    Applications are due September 21 for funded travel to and attendance at the mobilize workshop, Rapid Biomedical Knowledge Base Construction from Text, at Stanford University. The November workshop is free to attend, but space is limited.

  • Don’t Miss the 2019 Science of Team Science (SciTS) Conference May 20-23, 2019 in Lansing, Michigan!
    September 12th, 2018

    The Science of Team Science conference is the annual international forum dedicated to bringing together thought leaders and practitioners from a broad range of disciplines, fields, and professions. Click the title above to learn more, including the abstract submission and registration deadlines. 

  • FDA offers Clinical Investigator Training Course in November
    September 10th, 2018
    Experts from FDA’s Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER), Center for Devices and Radiological Health (CDRH), the University of Maryland, and the University of Pennsylvania will provide a deep dive into the scientific background and practical methodology needed when conducting clinical trials.
  • The Great CTSA Team Science Contest
    September 4th, 2018
    The purpose of this contest is to find the best ideas in all of CTSA-land for encouraging better team science. Any person associated with a CTSA hub is eligible. Click the title above to learn more. 
  • NCATS Director's Corner
    June 7th, 2018

    Translating Translation "NCATS is unique at NIH in that the name in the Center’s mission — “translation” — has a firmly established meaning that is generally associated with languages, not biomedical research. By contrast, other NIH components are named for widely known medical problems, such as cancer, diabetes and stroke." 

  • Crafting a Science News Release
    June 4th, 2018

    "The modern news release is now directly consumed by the public. Here are some of the best practices gathered by NIH communications offices for writing clear news releases that also inform the public about a scientific finding."

  • Be Skeptical About Biomarkers and Surrogate Endpoints
    June 4th, 2018

    In late April, Dr. Mike Lauer, NIH Deputy Director for Extramural Reserach, wrote about the benefits and drawbacks of using surrogate endpoints in clinical trials. Read his thoughts here...

More News

Impact

Has the CTSI-CN has supported your research? Tell us about it here.  

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