Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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CTSI-CN Leadership Statement

The CTSI-CN offers our heartfelt condolences to the family of George Floyd and all victims of racism and prejudice. Our mission is to advance the health and well-being of our community, including its minority and underserved populations.

We will listen, we will learn, and we will think creatively about how research initiatives can help move us towards solutions.

Most importantly, we will not turn away. We will be present to support our researchers and our communities through this difficult time in our city and our nation.

  • Oct
    28
    Thu, 10/28/2021 - 16:00 to 17:00

    Join the CTSI-CN KL2 Special Interest SIG on October 28, 2021 at 12pm EDT as Dr. Janice Blanchard will present "Mentoring for differences: Lessons from Building Up"

  • Oct
    28
    Thu, 10/28/2021 - 16:00 to 18:00

    Have you ever borrowed code from a Medium blog post or a stack coverflow thread only to find that it doesn't work as advertised? Spent hours trying to figure out an error message? You might agree that debugging can be one of the most frustrating parts of programming. This intermediate-level workshop will introduce techniques for diagnosing errors in Python code and will cover some best practices that can make your code more robust, easier to maintain, and more reproducible.

  • Oct
    29
    Fri, 10/29/2021 - 10:00 to 12:00

    Building on a basic knowledge of R and introductory statistics, this workshop will walk you through the R functionality you'll need to use when conducting hypothesis tests on categorical data. We will practice reading in data, creating 2x2 tables, conducting tests of proportion, chi-square tests, and computing measures of association. It is recommended that you have used R before (even if you consider yourself a beginner) and it is also recommended that you have taken an introductory statistics course.

  • Oct
    29
    Fri, 10/29/2021 - 16:00 to 17:00

    In this workshop, participants will be able to access and use LAI's NVivo software; use basic functionalities of qualitative data analysis software for research; and find and access some of LAI's subscriptions for qualitative research.

  • Nov
    5
    Fri, 11/05/2021 - 10:00 to 12:00

    Building on basic knowledge of R and introductory statistics, this workshop will walk you through the R functionality you can use to compute correlations between continuous variables, fit and interpret both linear and logistic regression models, and compute associated confidence intervals. 

  • Nov
    12
    Fri, 11/12/2021 - 10:00 to 12:00

    Adding interactivity to your data visualizations allows users to manipulate the plot to ask different questions, explore detail, and more. Learn to make interactive, publication-quality web-based graphs in R using the RShiny package. It is recommended that you have used R before, even if you consider yourself a beginner.

  • Nov
    18
    Thu, 11/18/2021 - 14:00 to 15:30

    The George Washington University (GW) is committed to fostering a research environment guided by the highest standards of research ethics and integrity. Conducting research responsibly is crucial in obtaining objective results and maintaining the public’s trust as stewards of research funds. GW encourages all of its faculty and students to be familiar with general professional and ethical standards of academic research as well as those in their disciplines. Continuous Responsible Conduct of Research (RCR) training is a critical part of these efforts. 

  • Dec
    16
    Thu, 12/16/2021 - 14:00 to 15:30

    The George Washington University (GW) is committed to fostering a research environment guided by the highest standards of research ethics and integrity. Conducting research responsibly is crucial in obtaining objective results and maintaining the public’s trust as stewards of research funds. GW encourages all of its faculty and students to be familiar with general professional and ethical standards of academic research as well as those in their disciplines. Continuous Responsible Conduct of Research (RCR) training is a critical part of these efforts. 

  • September 10th, 2021

    I-ACT for Children, an independent, non-profit organization that works with research sites and industry to assure that studies are designed to generate sufficient data to allow safe and effective use of new medications and devices in pediatric populations has announced that it is accepting applications for the 2021 I-ACT for Children Educational Grant Program. The grant is designed specifically to support attendance at and/or participation in a research conference or course by early-stage investigators, study nurses or coordinators and research administration staff who support pediatric clinical trials. Apply by September 24, 2021!

     

  • September 9th, 2021

    Now accepting applications for the 2022-2023 Academic Year! The Global Health Initiative at Childrens National Hospital seeks to foster and encourage the development of research that addresses key pediatric global health challenges, improves health outcomes in resource-limited settings, and favorably positions faculty to obtain extramural funding in pediatric global health research. Projects to be considered must be conducted in a low or middle-income country (LMIC) on a pediatric topic of importance to that country and/or have direct relevance to emerging global threats. Proposals to study a health issue in a developing country that could be studied using a US population are not encouraged and will receive a lower score.

  • August 17th, 2021

    Join leading experts in Health Promotion, Disease and Injury Prevention, Workforce Innovation, Health Care Transformation, and Population Health. Currently accepting applicatons for a November 2021 appointment!

  • August 10th, 2021

    MGNet, a NIH-funded Rare Diseases Clinical Research Consortium (RDCRC) in partnership with the Myasthenia Gravis Foundation of America and Conquer MG, is seeking proposals for highly innovative investigations in early stages of development.

  • August 10th, 2021

    Life course research embraces the complexity of health and disease development, tackling the extensive interactions between genetics and the environment over a lifetime. Recent advances in computational analytics, computer science, and data collection allow for the integration of a “life course” theoretical framework and complexity science for understanding health and development across the lifespan.

  • August 10th, 2021

    There is a critical need for investigators prepared to conduct clinical and translational research in myasthenia gravis (MG). The MGNet Scholar Program provides individualized training and mentorship in one of two tracks, Clinical Research or Biomarker Development Research.

  • July 26th, 2021

    NIH-funded multi-year study will look at impacts on children’s physical health and quality of life

  • July 20th, 2021

    "Re-engineering the Clinical Research Enterprise in Response to COVID-19: The CTSA Experience" 
    The COVID-19 pandemic has been one of the greatest global public health crises of our lifetime. Across the country, institutions in the CTSA Program responded quickly to it, pivoting research and creating new programs to respond to the outbreak. This special theme issue of the Journal of Clinical and Translational Science (JCTS) reflects on these changes, shares lessons learned and discusses which practices can continue in the future to advance translational science.

  • July 13th, 2021

    By Kolaleh Eskandanian, PhD, MBA, PMP - Vice President and Chief Innovation Officer, Children’s National Hospital

  • June 8th, 2021

    Are you interested in translational science? Are you looking to further develop your career and network with peers? Join the Center for Leading Innovation and Collaboration (CLIC) Career Development Community!

  • June 8th, 2021

    Thank you for attending this year's 4th Annual Children's National - NIAID Symposium virtually. Your engagement contributed to the success of the symposium!

  • May 6th, 2021

    We are excited to host you at the 4th Annual Children's National - NIAID SymposiumThis annual symposium celebrates the partnership between Children’s National Hospital (CNH) and the National Institute of Allergy and Infectious Diseases (NIAID). Established in 2017, the CNH-NIAID partnership focuses on advancing the health of children with allergic, immunologic, and infectious diseases through collaborative research and education.

  • April 21st, 2021

    The Johns Hopkins University-Tufts Medical Center Trial Innovation Center (JHU-Tufts TIC) is looking for investigators who are interested in pursuing innovative clinical trial designs to participate in its annual Design Lab workshops.

     

  • April 20th, 2021

    The National Institutes of Health’s new ACTIV-6 trial will use #DrugRepurposing to test several existing drugs to determine whether they provide safe, effective symptom relief for mild to moderate #COVID19 symptoms at home.

  • April 7th, 2021

    April 12-16, 2021: The Global Health Initiative at Children's National Hospital is excited to announce the Spring 2021 Schedule! Each session is designed to meet specific objectives of the Global Health Curriculum.

Life course research embraces the complexity of health and disease development, tackling the extensive interactions between genetics and the environment over a lifetime. Recent advances in computational analytics, computer science, and data collection allow for the integration of a “life course” theoretical framework and complexity science for understanding health and development across the lifespan. Learn more about the Life Course Research Visual Toolkit here