Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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CTSI-CN Leadership Statement

The CTSI-CN offers our heartfelt condolences to the family of George Floyd and all victims of racism and prejudice. Our mission is to advance the health and well-being of our community, including its minority and underserved populations.

We will listen, we will learn, and we will think creatively about how research initiatives can help move us towards solutions.

Most importantly, we will not turn away. We will be present to support our researchers and our communities through this difficult time in our city and our nation.

  • Sep
    20
    Mon, 09/20/2021 - 09:30 to 14:30

    R is a programming language that is popular for data exploration, visualization, and statistical analysis. This workshop will introduce participants to basic R tasks such as reading data into R, analyzing data, and plotting data. No prior programming knowledge is required, just a basic understanding of computer files and folders.

  • Sep
    21
    Tue, 09/21/2021 - 14:00 to 15:00

    Update your ORCID Record to Save Time and Get Credit in Funding Applications, Publications, and Research Reporting

  • Sep
    23
    Thu, 09/23/2021 - 12:00 to 13:00

    Involved in research? Interested in receiving up to $50,000 per year to help repay your student loans? Join Matthew Lockhart, Acting Director of NIH Division of Loan Repayment and learn more about the Loan Repayment Programs (LRP), understand the application process, and get advice from colleagues who succesfully applied. The session will be followed by a Q&A with recent LRP recipients - Linda Herbert, PhD; Homa Ahmadzia, MD, MPH; and Beth Tarini, MD, MS

  • Sep
    23
    Thu, 09/23/2021 - 16:00 to 17:30

    Attendees will learn what social media APIs are and what data Twitter provides via its public APIs; understand how tools such as Social Feed Manager can be used to collect social media as data and the limitations on collecting; and be able to identify key ethical, legal, and privacy considerations are for working with social media data.

  • Sep
    23
    Thu, 09/23/2021 - 18:00 to 19:00

    After your research collection, do you wish you had a way to keep all your citations and pdfs in one place? Come learn about Zotero, "a free, easy-to-use tool to help you collect, organize, cite and share your research sources. Attendees will learn how the Zotero tool can be used to save citations and pdfs; how to create references and bibliographies; and how to access the enhanced features as GW affiliates.

  • Sep
    30
    Thu, 09/30/2021 - 16:00 to 17:00

    In this workshop, participants will be able to access and use LAI's NVivo software; use basic functionalities of qualitative data analysis software for research; and find and access some of LAI's subscriptions for qualitative research.

  • Oct
    7
    Thu, 10/07/2021 - 16:00 to 18:00

    Web scraping is a technique for extracting data from web pages using code, particularly when the data is not available to download or from an API. This hands-on intermediate Python workshop will guide participants through the use of the Python requests-html library for working with content on websites. Presenters will also cover ethical considerations, recommended practices, and other approaches for web scraping using Python. No Python installation is required: Google Colab notebooks will be used for coding during the workshop.

  • Oct
    8
    Fri, 10/08/2021 - 09:30 to 14:30

    R is a programming language that is popular for data exploration, visualization, and statistical analysis. This workshop will introduce participants to basic R tasks such as reading data into R, analyzing data, and plotting data. No prior programming knowledge is required, just a basic understanding of computer files and folders.

  • Oct
    8
    Fri, 10/08/2021 - 10:00 to 11:30

    This workshop is designed to support researchers interested in working with historic maps in a GIS. This includes overlaying historic maps on top of contemporary maps using QGIS software, which should be downloaded in advance of this session.

  • Oct
    11
    Mon, 10/11/2021 - 08:00 to Fri, 10/15/2021 - 17:00

    In collaboration with Children's National Hospital pediatric residency program, this free introductory course highlights several ares of global health practice. A mini-symposium on Immigrant Health will also be hosted by Children's National Hospital and the Global Health Initiativeon Monday, October 11th. In-person and Zoom options will be available.

  • Oct
    13
    Wed, 10/13/2021 - 11:30 to 13:30

    This intermediate-level workshop will introduce methods and tools for processing text and transforming it into data that can be analyzed. Participants will be introduced to the spacy Python library and basic methods of quantitative textual analysis. Prior exposure to Python, such as through the "Introduction to Python" workshop or Python Camp, is helpful. No installation of Python is needed.

  • Oct
    14
    Thu, 10/14/2021 - 15:00 to 16:00

    Join us on Thursday, October 14 at 3pm for a Responsible Conduct of Research Presentation: "Lessons learned from Jesse Gelsinger" with Dr. Mark Batshaw.

  • Oct
    15
    Fri, 10/15/2021 - 10:00 to 12:00

    Building on a basic knowledge of R and introductory statistics, this workshop will walk you through the R functionality you'll need to use when conducting hypothesis tests on continuous variables. We will practice reading in data, conducting t-tests (both parametric and non-parametric), tests of equal variance, ANOVA, computing confidence intervals, and interpreting associated outputs. It is recommended that you have used R before (even if you consider yourself a beginner) and it is also recommended that you have taken an introductory statistics course.

  • Oct
    18
    Mon, 10/18/2021 - 16:00 to 18:00

    Data in the wild can be messy, malformed, and/or generally ill-suited to the specifications of statistical analyses and machine-learning techniques. In this intermediate-level workshop, you'll learn how to use Python to clean, reshape, and transform data prior to analysis.

  • Oct
    21
    Thu, 10/21/2021 - 14:00 to 15:30

    The George Washington University (GW) is committed to fostering a research environment guided by the highest standards of research ethics and integrity. Conducting research responsibly is crucial in obtaining objective results and maintaining the public’s trust as stewards of research funds. GW encourages all of its faculty and students to be familiar with general professional and ethical standards of academic research as well as those in their disciplines. Continuous Responsible Conduct of Research (RCR) training is a critical part of these efforts. 

  • September 10th, 2021

    I-ACT for Children, an independent, non-profit organization that works with research sites and industry to assure that studies are designed to generate sufficient data to allow safe and effective use of new medications and devices in pediatric populations has announced that it is accepting applications for the 2021 I-ACT for Children Educational Grant Program. The grant is designed specifically to support attendance at and/or participation in a research conference or course by early-stage investigators, study nurses or coordinators and research administration staff who support pediatric clinical trials. Apply by September 24, 2021!

     

  • September 9th, 2021

    Now accepting applications for the 2022-2023 Academic Year! The Global Health Initiative at Childrens National Hospital seeks to foster and encourage the development of research that addresses key pediatric global health challenges, improves health outcomes in resource-limited settings, and favorably positions faculty to obtain extramural funding in pediatric global health research. Projects to be considered must be conducted in a low or middle-income country (LMIC) on a pediatric topic of importance to that country and/or have direct relevance to emerging global threats. Proposals to study a health issue in a developing country that could be studied using a US population are not encouraged and will receive a lower score.

  • August 17th, 2021

    Join leading experts in Health Promotion, Disease and Injury Prevention, Workforce Innovation, Health Care Transformation, and Population Health. Currently accepting applicatons for a November 2021 appointment!

  • August 10th, 2021

    MGNet, a NIH-funded Rare Diseases Clinical Research Consortium (RDCRC) in partnership with the Myasthenia Gravis Foundation of America and Conquer MG, is seeking proposals for highly innovative investigations in early stages of development.

  • August 10th, 2021

    Life course research embraces the complexity of health and disease development, tackling the extensive interactions between genetics and the environment over a lifetime. Recent advances in computational analytics, computer science, and data collection allow for the integration of a “life course” theoretical framework and complexity science for understanding health and development across the lifespan.

  • August 10th, 2021

    There is a critical need for investigators prepared to conduct clinical and translational research in myasthenia gravis (MG). The MGNet Scholar Program provides individualized training and mentorship in one of two tracks, Clinical Research or Biomarker Development Research.

  • July 26th, 2021

    NIH-funded multi-year study will look at impacts on children’s physical health and quality of life

  • July 20th, 2021

    "Re-engineering the Clinical Research Enterprise in Response to COVID-19: The CTSA Experience" 
    The COVID-19 pandemic has been one of the greatest global public health crises of our lifetime. Across the country, institutions in the CTSA Program responded quickly to it, pivoting research and creating new programs to respond to the outbreak. This special theme issue of the Journal of Clinical and Translational Science (JCTS) reflects on these changes, shares lessons learned and discusses which practices can continue in the future to advance translational science.

  • July 13th, 2021

    By Kolaleh Eskandanian, PhD, MBA, PMP - Vice President and Chief Innovation Officer, Children’s National Hospital

  • June 8th, 2021

    Are you interested in translational science? Are you looking to further develop your career and network with peers? Join the Center for Leading Innovation and Collaboration (CLIC) Career Development Community!

  • June 8th, 2021

    Thank you for attending this year's 4th Annual Children's National - NIAID Symposium virtually. Your engagement contributed to the success of the symposium!

  • May 6th, 2021

    We are excited to host you at the 4th Annual Children's National - NIAID SymposiumThis annual symposium celebrates the partnership between Children’s National Hospital (CNH) and the National Institute of Allergy and Infectious Diseases (NIAID). Established in 2017, the CNH-NIAID partnership focuses on advancing the health of children with allergic, immunologic, and infectious diseases through collaborative research and education.

  • April 21st, 2021

    The Johns Hopkins University-Tufts Medical Center Trial Innovation Center (JHU-Tufts TIC) is looking for investigators who are interested in pursuing innovative clinical trial designs to participate in its annual Design Lab workshops.

     

  • April 20th, 2021

    The National Institutes of Health’s new ACTIV-6 trial will use #DrugRepurposing to test several existing drugs to determine whether they provide safe, effective symptom relief for mild to moderate #COVID19 symptoms at home.

  • April 7th, 2021

    April 12-16, 2021: The Global Health Initiative at Children's National Hospital is excited to announce the Spring 2021 Schedule! Each session is designed to meet specific objectives of the Global Health Curriculum.

Life course research embraces the complexity of health and disease development, tackling the extensive interactions between genetics and the environment over a lifetime. Recent advances in computational analytics, computer science, and data collection allow for the integration of a “life course” theoretical framework and complexity science for understanding health and development across the lifespan. Learn more about the Life Course Research Visual Toolkit here