Basic Research
Basic research involves scientific exploration that can reveal fundamental mechanisms of biology, disease or behavior. Every stage of the translational research spectrum builds upon and informs basic research. NCATS scientists typically do not conduct basic research; however, insights gained from the Center’s studies along the translational spectrum can inform basic research.
Pre-Clinical Research
Pre-clinical research connects the basic science of disease with human medicine. During this stage, scientists develop model interventions to further understand the basis of a disease or disorder and find ways to treat it. Testing is carried out using cell or animal models of disease; samples of human or animal tissues; or computer-assisted simulations of drug, device or diagnostic interactions within living systems.
Clinical Research
Clinical research includes studies to better understand a disease in humans and relate this knowledge to findings in cell or animal models; testing and refinement of new technologies in people; testing of interventions for safety and effectiveness in those with or without disease; behavioral and observational studies; and outcomes and health services research. The goal of many clinical trials is to obtain data to support regulatory approval for an intervention.
Clinical Implementation
The clinical implementation stage of translation involves the adoption of interventions that have been demonstrated to be useful in a research environment into routine clinical care for the general population. This stage also includes implementation research to evaluate the results of clinical trials and to identify new clinical questions and gaps in care.
Public Health
In this stage of translation, researchers study health outcomes at the population level to determine the effects of diseases and efforts to prevent, diagnose and treat them. Findings help guide scientists working to assess the effects of current interventions and to develop new ones.
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CTSI-CN Leadership Statement

The CTSI-CN offers our heartfelt condolences to the family of George Floyd and all victims of racism and prejudice. Our mission is to advance the health and well-being of our community, including its minority and underserved populations.

We will listen, we will learn, and we will think creatively about how research initiatives can help move us towards solutions.

Most importantly, we will not turn away. We will be present to support our researchers and our communities through this difficult time in our city and our nation.

Events

  • Sep
    29
    3rd Annual CN-NIAID Virtual Symposium
    Tue, 09/29/2020 - 09:00 to 16:00

    Save the date and join us on Tuesday, September 29th for this virtual symposium!

  • Oct
    1
    K-SIG: NIH Loan Repayment Programs
    Thu, 10/01/2020 - 12:00 to 13:00

    Involved in research? Interested in receiving up to $50,000/year to help repay your student loans? Join us via Zoom to learn more about these federal assistance programs, understand the application process, and get advice from colleagues who successfully applied.

     

  • Oct
    8
    ResearchMatch Researcher Training
    Thu, 10/08/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Oct
    14
    RCR Series: ORI Research Misconduct Investigations
    Wed, 10/14/2020 - 13:00 to 15:00

    The Responsible Conduct of Research Series at Children's National Hospital is pleased to host guests from the Office of Research Integrity for a presentation and discussion on research misconduct investigations.

  • Nov
    12
    ResearchMatch Researcher Training
    Thu, 11/12/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

  • Dec
    10
    ResearchMatch Researcher Training
    Thu, 12/10/2020 - 15:00 to 16:00

    ResearchMatch is a free participant recruitment and feasibility analysis tool for researchers at participating institutions. The tool is offered to researchers who are conducting research which is health related.

More Events

News

More News

Join us at the next 3rd Annual CN-NIAID VIRTUAL Symposium

This year, the event will highlight the current COVID-19 and MIS-C pandemic, with a specific focus on the pediatric population. Dr. Anthony Fauci, Director of NIAID, will provide an overview on the infectious disease, and leading experts from Children’s National, NIAID, and other institutions will share the novel research and science being done to address this worldwide issue.

Learn more about the partnership and register for this event at https://ctsicn.org/cn-niaid