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Cohort Discovery & Feasibility

The Clinical and Translational Science Institute at Children's National (CTSI-CN) is proud to support Children's National Hospital and George Washington University research faculty and staff by providing a variety of supportive resources and tools. 

The Informatics Core, in partnership with the Liaison to Recruitment Innovation Centers module provides access to and support for the following Cohort Discovery & Feasibility tools:

i2b2 / SHRINE

i2b2, or Informatics for Integrating Biology & the Bedside, is an NIH-funded scalable informatics framework that links data warehouses across partner institutions. Locally, i2b2 facilitates exploration and query of the clinical data within PowerChart that has been de-identified and aggregated. In doing so, i2b2 helps with study feasibility and cohort discovery by allowing a researcher to query various inclusion/exclusion criteria, as well as ascertain the potential for recruitment.

SHRINE, or the Shared Health Research Information Network, is integrated into the i2b2 platform and supports multi-site research by enabling study feasibility and cohort discovery at partnered institutions.

At Children’s National Hospital, both i2b2 and SHRINE are support by CTSI-CN's Bear INformatic System for Integrating Genomics, Health and Translational Sciences (BearINSIGHTS) program.

Please Note: As both tools currently only allow access to de-identified, aggregate data no IRB approval is required.

To learn more about i2b2/SHRINE please visit: i2b2/SHRINE


TriNetX is a dynamic, data driven platform that leverages the i2b2 data warehouse and Cerner PowerChart (EHR). Employing a clean and easily navigable user interface, a research easily generate a query to perform study feasibility and cohort discovery. Additionally, TriNetX has the ability to perform analysis of the identified cohort and “estimated rate of arrival” projections. TriNetX is a valuable resource for accelerating the conduct of both investigator-initiated and industry research.

As of March 2018, with the addition of "TriNetX Research" TriNetX now offers the ability to collaborate with Health Care Organizations (HCO) from around the world to conduct real world evidence (RWE) research.

Please Note: As TriNetX currently only allows access to de-identified, aggregate data, no IRB approval is required. 

To learn more about TriNetX please visit: TriNetX

ResearchMatch (for Researchers)

ResearchMatch is a NIH-funded, national registry that brings together researchers and 125,000+ volunteers who are interested in learning more about research studies. Used nationally by over 5,700 researchers this novel platform has been helpful in recruiting research participants across many research areas, and has been particularly useful for research involving rare disease, surveys, and healthy volunteers.

To learn more about ResearchMatch (for Researchers) please visit: ResearchMatch (for Researchers)