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Genomics / Proteomics

Children's National Core Facilities

Genetic and Proteomics Core

The Center for Genetic Medicine Research and the Department of Integrated Systems Biology host a series of regional and national core facilities. The goal of these core facilities is to facilitate research across the institute as well as external laboratories, through applications of specialized technologies and expertise to investigators’ projects. The core houses state-of-the-art equipment purchased through institutional funds, philanthropic donations, and research grants, totaling more than $10 million. Providing other investigators easy access to these facilities and equipment is an important value shared by the faculty. 

Genomics/Proteomics capabilities are designed to support rigorous CTR investigations and training by:

  • Providing state-of-the-art emerging technologies for clinical and translational research
  • Offering specialized resources from design through analysis for large or small projects
  • Moving high-value novel methodologies and discoveries from innovation to implementation

Sample Services:

  • Sequencing (whole exome, targeted, microbiome, RNA/miRNA)
  • Illumina and Affymetrix Arrays (profiling, methylation, transcriptome, etc.)
  • Mass Spectrometry (metabolomics, labeled proteomics, post-translational modifications), 2-D Gel
  • Bioinformatics, Statistical Genetic Analysis
  • SNP analysis, ELISA, NanoString, RT-PCR

Contacts:

  • DNA and mRNA technologies: Eric Hoffman, PhD; Susan Knoblach, PhD
  • Proteomics technologies: Kristy Brown, PhD; Susan Knoblach, PhD
  • Microscopy: Jyoti Jaiswal, PhD
  • Pre-clinical murine drug testing: Kanneboyina Nagaraju, DVM, PhD
  • Bioinformatics: Eric Hoffman, PhD; Susan Knoblach, PhD; Zuyi Wang, PhD