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National COVID Cohort Collaborative (N3C)

The National Institutes of Health launched the National COVID Cohort Collaborative (N3C) Data Enclave, and researchers studying COVID-19 can apply to access this innovative new analytics platform containing clinical data from the electronic health records of people who were tested for the novel coronavirus or who had related symptoms. This data resource will help scientists further understand the disease, including potential risk factors, protective factors and long-term health consequences. The N3C is funded by the National Center for Advancing Translational Sciences (NCATS). 

  • Access to over 900,000 COVID-19 Electronic Health Records
  • Define the impact of medical interventions or situation factors across time
  • Determine the impact of socioeconomic factors
  • Isolate data by a wide range of variables: lab results, patient notes, diagnosis, concurrent conditions, ethnicity, etc.

To get started:

 Sign-up to N3C by completing each of the tasks below

 

  1. Register with N3C
    Click here to Register with N3C.

    Upon approval, researchers will receive an email with directions for signing into their N3C Data Enclave account.

    Please fill out the N3C registration form and request an Enclave account by checking the “Access to the N3C Data Enclave” box. Once an account has been generated, an email with further instructions will be sent to the email address provided. If you need to update your profile information you can do so here. NOTE: N3C members who previously had accounts for accessing Palantir training will have to re-register for a new N3C Data Enclave account to gain access.
     
  2. Log into the N3C Data Enclave
    Following the directions provided in the account creation email, researchers need to log into the N3C Data Enclave to access their account and resources for learning about using the N3C Data Enclave. Having an N3C Data Enclave account does not on its own enable access to the N3C data, however. (Scroll down to view the N3C Intro Access video)
     
  3. Complete required training
    The N3C Data Enclave is hosted by NCATS, and all researchers must complete the “Information Security, Counterintelligence, Privacy Awareness, Records Management Refresher, Emergency Preparedness Refresher” course, which can be accessed at NIH’s information security training website, before submitting a DUR. It will take approximately 60-90 minutes to complete the entire course and users should save evidence of completion for their records (a screenshot or copy of the certificate of completion). Researchers who will request access to de-identified data or to the Limited Data Set (LDS) also must have completed their home institution’s human subjects research training requirements. Researchers will be required to provide the date they completed training in their DUR.
     
  4. Submit the Data Use Request
    After satisfying the training requirements, researchers must fill out and submit a DUR through the N3C Data Enclave. (See a sample DUR form.) Researchers will need to provide a project title, a public research statement, a description of their research project plan, the level of data they intend to access and other information. Researchers also must read and attest to the DUA and to the N3C Data User Code of Conduct. If requesting access to the LDS, researchers will need to provide a copy of their institution’s Human Research Protection Program IRB determination letter. For more details about the DUR, see the N3C Data Access Forms and Resources page.

Contact

If you have issues completing the above process, or need more information, please email Darryl Grant.

how-to resources

N3C Intro Access

N3C Project Development

N3C Demonstration (Photo/Video Credit: NIH-NCATS)